Harley Street nthawi zambiri imatchedwa “London Medical” chifukwa chakuti ili ndi imodzi mwazinthu zazikulu kwambiri zachipatala padziko lapansi. Ndi mbiri yakale monga likulu lazachipatala payekha, Mayanjano oyambilira a Harley Street ndi mankhwala amatha kutsatiridwa mozungulira 1860 pamene madokotala ambiri adasamukira kuderali chifukwa cha malo apakati komanso pafupi ndi masiteshoni akuluakulu a sitima, monga Kings Cross, St Pancras ndi Marylebone. Kuyambira m'ma chakhumi ndi chisanu ndi chinayi chiwerengero cha madokotala, zipatala, zipatala za opaleshoni ya maso ndi mabungwe ena azachipatala omwe ali mkati ndi kuzungulira dera la Harley Street awonjezeka kwambiri. Anali ozungulira 20 madokotala omwe amagwira ntchito m'derali 1860 ndi kuwonjezeka kakhumi kunalembedwa ndi 1914 pamene chiwerengerocho chinakwera 200. Zina ziwiri zomwe zalandiridwa kuderali zomwe zidapititsa patsogolo mbiri yaderali zinali Medical Society of London, yomwe idatsegulidwa mu Chandos Street mu 1873 ndi Royal Society of Medicine yomwe idayamba 1912 pa Wimpole Street.Kwa zaka zambiri Harley Street wakhala kunyumba kwa akatswiri ambiri otchuka azachipatala. Sir Henry Thompson, dokotala wamkulu waku Britain ndi polymath, adachitidwa m'derali m'zaka za m'ma 1870 ndipo adasankhidwa kukhala dokotala wamkulu wa opaleshoni kwa Mfumu ya Brussels.Dokotala Edward Bach adachita kuchokera ku Harley Street m'zaka za m'ma 1920 asanasamukire ku London Homeopathic Hospital kenako ndikupanga Bach Flower Remedies omwe akudziwikabe mpaka pano.. Nthawi zasintha kuyambira zaka za m'ma 1900 pomwe asing'anga akadapanga opareshoni kunyumba kwawo ndikukonza nthawi yawoyawo ndipo Harley Street ikupitilizabe kuchita bwino ngati likulu lazinthu zonse zamankhwala.. Mosafunikira kunena kuti zipatala zopezeka pano zimapereka umisiri waposachedwa limodzi ndi ukatswiri wina wamankhwala mdziko muno.Lero zatha 3,000 anthu ogwira ntchito m'dera lomwe limapereka chithandizo chamankhwala osiyanasiyana, kuchokera kuchipatala chothandizira kupita ku opaleshoni yapulasitiki. Chifukwa chake ngati mukuyang'ana opareshoni yamaso ya laser ku London kapena mukungofunika kulembetsa ndi GP mukutsimikiza kuti mupeza zomwe mukufuna pano Harley Street imapanga malo abwino kwambiri omwe mungachitireko ndipo derali likupitilizabe kukopa akatswiri ambiri azachipatala., kuchokera kwa maopaleshoni a maso ndi madotolo mpaka amisala ndi maopaleshoni apulasitiki. Ngati mukufuna kupita ku Harley Street kukakumana ndiye kuti muli ndi njira zingapo zomwe mungasankhe. Ngati mutagwira chubu mutha kutsika pa Bond Street kapena Oxford Circus kudera lakumwera kwambiri, pomwe Regents Park ndi Great Portland Street zili kumpoto kuti mutha kugwira chubu kuti mugwirizane ndi komwe mukupita.. Apanso, Malo okwerera masitima apamtunda a Marylebone ndi Euston onse ali pafupi ndipo malo oimika magalimoto ku Portland Place ndi Harley Street amapangitsa moyo kukhala wosavuta kwa iwo omwe amafika pagalimoto..